Anti-microbial resistant in Gram-negative bacteria bacillus: Enterobacteriaceae and non-fermenting bacilli isolated at Sominé DOLO Hospital of Mopti, Mali
نویسندگان
چکیده
Background: β-lactams and carbapenems are the major antibiotics used to treat gram-negative bacteria non-fermenting bacilli. However, increasing production of β-lactamase carbapenemase limits therapeutic options. Our study aims determine resistant phenotypes these while describing their epidemiological aspect. Material Methods: This was a cross-sectional by consecutive enrollment from January 2018 December 2019 at Sominé DOLO Hospital Mopti, Mali. We performed manual method for culture, identification sensitivity testing. The testing accessed diffusion according CA-SFM/EUCAST (“Comité de l’Antibiogramme la Société Française Microbiologie” / European Committee on Antimicrobial Susceptibility Testing) recommendations V1.0 february V2.0 may V.2.0. May recommendation released in 2019. Data were analyzed software R 4.0.3 GUI 1.73 Catalina build (7892). Results: At all 904 samples included this study. Out cultures, 297 sample (32.85%) positive. rates enzymes as follow: Extended-spectrum ß-lactamase (ESBL) 56.42% (101/179), cepholosporinase hyperproduction (HCASE) 15.64% (28/179), cephalosporinase (CASE) 6.14% (11/179), penicillinase (HP) 5.58% (10/179), (CP) (11/179) savage strains 10.05% (18/179). Conclusion: data showed high prevalence resistance β-lactamins carbapenemes bacillus A level gram negative bacillius also reported others authors calls rational use antibiotic hospital setting.
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ژورنال
عنوان ژورنال: GSC biological and pharmaceutical sciences
سال: 2022
ISSN: ['2581-3250']
DOI: https://doi.org/10.30574/gscbps.2022.18.1.0021